Department of Pharmacology & Clinical Pharmacy

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30

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24

Academic Staff

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Department of Pharmacology & Clinical Pharmacy has more than 24 academic staff members

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Prof.Dr. ِALI MANSOUR SADEK GIURNAZI

ِALI GIURNAZI is one of the staff members at the department of 1 faculty of 5. He is working as a since 2008-08-29. He teaches several subjects in his major and has several puplications in the field of his interest.

Publications

Some of publications in Department of Pharmacology & Clinical Pharmacy

A retrospective study of Leukemia in Libyan children

اللوكيميا هو سرطان يصيب الأنسجة التي تنتج خلايا الدم وينتج عنها خلايا غير طبيعية. اللوكيميا لها عدة أشكال ، اثنان منها شائعان بشكل خاص بين الأطفال الذين تتراوح أعمارهم بين شهر واحد حتى 16 عامًا. تُعرف باسم ابيضاض الدم الليمفاوي الحاد (ALL) وسرطان الدم النقوي الحاد (AML). هذا العمل تم إجراؤه في مركز طرابلس الطبي (TMC) بأثر رجعي بقسم أورام الأطفال و دراسة لسرطان الدم ل 50 طفلاً ليبيًا ممن يعانون من ابيضاض الدم. أجريت دراسة تغطي الفترة بين 1997 و 2003 لوصف انتشار أكثر أنواع اللوكيميا شيوعًا وعلاقته بالتاريخ العائلي والعمر والجنس. كما يتم تقييم معدل الشفاء بعد العلاج الكيميائي. وأظهرت النتائج أن ALL (73٪) و AML (26٪) هما أكثر أنواع اللوكيميا شيوعًا بين الأطفال. بغض النظر عن نوع الجنس ، تم تسجيل أعلى نسبة بين النوع شهر و 8 سنوات من العمر. الإصابة عند الذكور أعلى من تلك عند الإناث. وفي الوقت نفسه ، لم يلاحظ أي علاقة بين الإصابة بسرطان الدم والتاريخ العائلي. تم الإبلاغ سريريًا عن أعلى حالات سرطان الدم لدى هؤلاء الأطفال في عام 1997 (24٪) وفي عام 2003 (22٪). كانت الأعراض الأكثر شيوعًا التي تم الإبلاغ عنها فيما بينها على وجه التحديد الحمى وفقدان الوزن والتعب. أدت بروتوكولات العلاج الكيميائي المطبقة إلى الشفاء في 88٪ من الحالات في حين تم تمثيل الوفيات في 12٪ من جميع الحالات. باختصار هناك حاجة لمزيد من الدراسات الاوسع عددا لتحديد المرضى المعرضين لخطر كبير من الفشل العلاجي لذلك ، مما سيعطي فرصة أكبر للشفاء من سرطان دم الاطفال
Hanan S. Abushwereb(4-2016)
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A simple validated HPTLC method for the analysis of flavonoids and molecular docking studies of novel tri-terpenoid glycoside isolated from Carya illinoinensis bark with potential anti-inflammatory and antinociceptive activities

Abstract Carya illinoinensis (Family Juglandaceae) is frequently used in traditional medicine for its antimicrobial, antioxidant, anti-rheumatic, anti-diabetic, and diuretic activities. Column chromatography was used to separate phytoconstituents from an ethanolic extract of powered bark. The terpenoid glycosidic compound, CI-01, was isolated as light-yellow crystalline powder in 0.33% (w/w) yield having melting point 94–96 °C, RF value 0.57 (in MeOH:CHCl3;20:80), UV absorption maxima 242 nm in methanol and molecular ion [M + H]+ peak at 420.4 m/z. Based on high-performance thin-layer chromatography and spectral data, the isolated compound CI-01, was identified as Farnesoic acid -l-glucoside. The ethanolic extract of Carya illinoinensis (CIE) at doses of 100 and 200 mg/kg and isolated compound CI-01 at 10 mg/kg dose were used for studying anti-inflammatory and antinociceptive effects. After 5 h of treatment with CI-01, the mean increase in paw volume was 0.459 ± 0.054 ml, which is corresponding to the standard drug indomethacin's 0.443 ± 0.041 ml. However, CIE groups receiving 100 and 200 mg/kg exhibited 0.518 ± 0.068 and 0.486 ± 0.048 ml, respectively. Compared to the control group of mice, animals treated with CIE and CI-01 dramatically reduced the number of writhes caused by acetic acid. AutoDock Vina program was used for molecular docking of the compound CI-01 with various targets, including COX-1, COX-2, inducible nitric oxide synthase, tumor necrosis factor-α, and opioid receptors exhibiting mean binding energies of -5.36, -7.37, -7.24, -4.27, and -7.04 kcal/mol, respectively. In conclusion, CI-01, isolated from Carya illinoinensis extract, demonstrated anti-inflammatory and antinociceptive activities at a dose of 10 mg/kg and displayed promising interaction with COX-2 in molecular docking study.
Ghazalla Mohamed Ali Benhusein(7-2022)
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Effect of Tamoxifen on Ethanol Induced Gastric Ulcer in Rats

Background: Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer, some literatures reported its impact on the process of peroxidation. Aim: The aim of this study was to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats. Method: Gastric ulcers were induced in Wistar albino rats by oral administration of absolute alcohol (1 ml/200 g). Antiulcer activity of tamoxifen (0.5 and 10 mg/kg, p.o.) was observed and compared to standard drug (omeprazole 20mg/kg, p.o.), the ulcer index, ulcers numbers, lengths, gastric volume and total gastric acidity were evaluated. Histopathology is performed for confirmation. Results: Tamoxifen in 10mg/kg dose produced a highly significant (P
Malak jafari, Al-Asayed R. Al-Attar(4-2021)
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