Background and Objectives: Compliance of community pharmacies with the proper practice of storage and dispensing of medicines is crucial for ensuring the quality and safety of medicines, particularly with the circumstance of recurrent electricity blackout in Libya. This study was aimed to assess the compliance of community pharmacies with the proper practice of drug storage in Tripoli city, Libya. Materials and Methods: A cross-sectional survey conducted in November 2020 targeting a total of 56 community pharmacies in Tripoli, Libya. The questionnaire was adapted from the WHO Checklist for Good Storage Practices and included 41 questions organized under five sections: socio-demographics, pharmacist’s attitude toward the quality of storage practices, queries on environmental storage conditions, the quality of facilities in the community pharmacy, and queries on storage and pharmacy practices. Data were presented as descriptive statistics. Results: Out of the total 56 visited pharmacies, a total of 46 (82.1%) pharmacists participated in the study with one pharmacist being interviewed in every pharmacy. Results showed that 15% of employees reported variety of cleanliness regulatory depending on cutting off running water circumstances in Tripoli and other reasons. About 78.8% participants observed dust in shelves and over the drugs packaging, and 22% of the participant pharmacies’ drugs exposure to direct sunlight. Additionally, 72% of employee experienced high temperatures in the pharmacy during electricity blackouts, whereas only 48% of them experienced humidity. In addition, 91.4% had alternative source of electricity, 44.3% had a power backup connected to the refrigerators. Conclusion: The compliance of majority of the community pharmacies operated in Tripoli is below standard. There is still need to improve the storage practices in the community pharmacies by obeying with the regulatory standards as specified by the Drug Regulatory Authority of Libya.
Ahmed Elbadri M Atia(5-2021)

Abstract Back ground: Full coverage porcelain fused to metal crowns (PFM) is commonly recommended for restoration of extensively damaged teeth. Ability of the dentist to adequately prepare teeth is necessary to achieve a proper success and longevity of these restoration. Aims: This study aimed to determine the degree of axial taper and total occlusal convergence angles (TOC) for Porcelain Fused To Metal crowns (PFM) prepared with clinically practiced values, that carried out by dental practitioners in Tripoli center, Libya. Materials and Methods: It was a descriptive, cross-sectional study design and held at Alzendah private dental laboratory, Tripoli Libya. A convenience sample (40) models of Porcelain Fused To Metal Crowns (PFM) preparations carried out by private dental practitioners were scanned by employing a 3D model scanner (Ceramill Map300, Amanngirrbach, Austria). Evaluation of the total occlusal convergence (TOC), bucco-lingual and mesio-distal convergence angles of each abutment tooth was proceeded using B&B dental software (Guide system, B&B, Italy). The degree of taper was measured on the axial walls of each crown preparation and the bucco-lingual and mesio-distal convergence angles subsequently calculated. Results: A total of 40 casts having crown preparations (15 anterior, 25 posterior). The mean convergence angles mesio-distally for all preparations was 40.29° (sd 21.8°), and for the bucco-lingual was 29.92° (sd 9.3°), with mean of TOC was 35.10°. In anterior preparations, the mean bucco-lingual convergence angle was 42.32° (sd 12.2°) compared to 24.52° (sd 15.5°) for posterior preparations (p
Dr. Khaled Omar & Abdussalam Eljabali(1-2022)

The most common preparation of tocotrienols is the tocotrienol-rich fraction (TRF). This study aimed to investigate whether TRF induced liver Nrf2 nuclear translocation and influenced the expression of Nrf2-regulated genes. Methods: In the Nrf2 induction study, mice were divided into control, 2000 mg/kg TRF and diethyl maleate treated groups. After acute treatment, mice were sacrificed at specific time points. Liver nuclear extracts were prepared and Nrf2 nuclear translocation was detected through Western blotting. To determine the effect of increasing doses of TRF on the extent of liver nuclear Nrf2 translocation and its implication on the expression levels of several Nrf2-regulated genes, mice were divided into 5 groups (control, 200, 500 and 1000 mg/kg TRF, and butylated hydroxyanisole-treated groups). After 14 days, mice were sacrificed and liver RNA extracted for qPCR assay. Results: 2000 mg/kg TRF administration initiated Nrf2 nuclear translocation within 30 min, reached maximum level around 1 h and dropped to half-maximal levels by 24 h. Incremental doses of TRF resulted in dose-dependent increases in liver Nrf2 nuclear levels, along with concomitant dose-dependent increases in the expressions of Nrf2-regulated genes. Conclusion: TRF activated the liver Nrf2 pathway resulting in increased expression of Nrf2-regulated cytoprotective genes.
Ahmed Elbadri M Atia(9-2020)