Objectives: The objective of this study is to study the demographic, clinicopathological features, and geographical distribution of differentiated thyroid cancer (DTC) among Libyan patients referred from all parts of the country to the nuclear medicine department, for radioactive iodine (RAI) therapy.Materials and Methods: Retrospective review of medical records of 265 patients with differentiated thyroid carcinoma (DTC) referred to RAI therapy in the Nuclear Medicine Branch‑Tripoli Medical Center, in the period from May 2005 to October 2010. The data analyzed included sex, age at the time of diagnosis, the city of residence, pathological diagnosis, the extent of disease, and types of treatment.Results: There were 225 (84.9%) females and 40 (15.1%) males giving a sex ratio of 5.6:1. The mean age of males at diagnosis was 51.2 ± 14.8 (range 24–78) years and  the  mean age  of  the  females was  44.6 ± 15.6 (range 10–95) years. Two  hundred and  twenty‑three (84.2%) had  papillary thyroid cancer (PTC), 31 (11.7%) had  follicular thyroid cancer, 3 (1.1%) had  Hurthle cell  thyroid cancer, and  2 (0.8%) had follicular‑insular thyroid cancer. About 43 (16.2%) had  a  history of  multinodular goiter, and  3 (1.1%) Hashimoto’s thyroiditis. From data  collected, cervical lymph node metastases were found in 45 (17.0%), and distal metastases in 27 (10.2%).Conclusions: PTC was the most common type of DTC. DTC was more common among females. The current study showed that the disease tends to occur at an older age, and with less cervical lymph node metastases than previously reported.
Hawa Juma El-Shareif(3-2018)

Angiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts showed a dose-dependent response which was compared with the anti-angiogenic activity of the positive controls silibinin, and lenalidomide. The extracts were also studied for their lipoxygenase (LOX) inhibitory potential and compared to ascorbic acid as the positive control. The IC50 values of the petroleum ether extract, ethanol extract, and ascorbic acid for LOX inhibition assay were 135.4, 113.1, and 41.5 mg/mL, respectively. Although both the extracts showed similar responses in CAM assay, ethanol extract proved to be more potent in LOX inhibition assay. Finally, the extracts were investigated for their chemical composition using GC-MS. A correlation between LOX inhibition and anti-angiogenic potential was established at the molecular level. A meticulous literature search was carried out to correlate the biochemical composition of the extracts to their anti-angiogenic activity arabic 19 English 119
Sandesh J. Marathe, Abdulla Bashein(1-2021)

Objectives: Tobacco use in all its forms represents a very well-known preventable risk factor for cardiovascular diseases (CVD). Alteration of plasma lipids levels is one of the mechanisms by which it causes CVD. In addition, there are controversial reports linking tobacco use with diabetes. This case-control study is aiming to investigate the interrelationship between tobacco use and BMI, lipid profile, and plasma glucose in Libyans residing in Tripoli region. Methods: The study was conducted on 200 healthy male subjects, including, 50 non-smokers aged 40.98±8.07, 50 cigarette smokers aged 41.32±7.39, 50 water-pipe users aged 42.04±7.39, and 50 snuff inhalers aged 39.36±7.00. BMI was estimated as (kg/m 2), lipid profile and fasting plasma glucose were estimated in triplicate by enzymatic colorimetric method and expressed as (mg/dL). Results: Our results showed that BMI is significantly higher in tobacco users than non-smokers (P 0.0001). Total cholesterol and triacylglycerols are significantly higher in tobacco users (P 0.0001). HDL is significantly higher in non-smokers (P 0.0001). LDL not affected by tobacco use (P 0.32). Fasting plasma glucose significantly higher in tobacco users (P 0.0001). Conclusions: In conclusion, tobacco use affects the BMI, lipid profile, and glucose which are components of the metabolic syndrome in the Libyan males population. arabic 31 English 133
H Alemam, Abdulla Bashein, (1-2015)