Department of Industrial Pharmacy

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About Department of Industrial Pharmacy

Facts about Department of Industrial Pharmacy

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3

Publications

13

Academic Staff

Who works at the Department of Industrial Pharmacy

Department of Industrial Pharmacy has more than 13 academic staff members

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Dr. Amina Mohamed A Almarzouki

Amina Almarzouki is one of the staff members at the department of 2 faculty of 5. He is working as a since 2016-01-24. He teaches several subjects in his major and has several puplications in the field of his interest.

Publications

Some of publications in Department of Industrial Pharmacy

Comparative in-vitro Evaluation of Some Desloratadine Tablets Marketed in Tripoli Libya

Abstract Background and aims. Desloratadine is a tricyclic, potent, rapidly effective, long acting, non-sedative antihistamine, which has a selective and peripheral H1 receptor antagonist action, used to treat the allergies. The availability of several brands of Desloratadine tablets in Libyan pharmacies today places health practitioners and a pharmacist in a problem of drug substitution in case of a particular brand is not available. The aim of the present study was the evaluation and comparison of pharmaceutical equivalence of five different Desloratadine tablets 5 mg, which are commercially available in the private pharmacies in Tripoli city with different price ranges, produced by various pharmaceutical companies. Methods. The pharmaceutical evaluation of five brands of Desloratadine tablets were done using official and unofficial quality control tests prescribed in different Pharmacopoeia including uniformity of weight, thickness, hardness, disintegration time, drug content as well as dissolution rate and identification test. Acceptable external features as well as uniformity in diameter and thickness were revealed for all the tablets. Results. The entire selected brands complied with the official specifications for uniformity of weight, hardness and disintegration, more than 80% of their drug dissolved in the medium within 60 minutes. Conclusion. It can be concluded that all the brands could be regarded as bioequivalent and therefore can be interchanged in the clinical practice; this sort of study is good indicator for the evaluation of the idealness of commercial products and showed the importance of post marketing investigation for the drugs imported and distributed in Libya.
tamader youssef salem elghnimi, Wadiaa Abubaker Ali Ben Amer, Rehab Rmadan Ibrahim Walli(12-2022)
Publisher's website

Comparative in-vitro Evaluation of Carbamazepine 200mg Tablets

Abstract: Carbamazepine (CBZ) is widely used as an antiepileptic drug, primarily for the treatment of partial and tonic-clonic seizures. Bipolar disorder can be treated by this medicine it also can be used in treatment of neurological pain and trigeminal neuralgia. The drug is absorbed slowly and has irregular gastrointestinal absorption after oral administration due to its limited water solubility. The main purpose of the present study was to compare pharmaceutical quality of different Carbamazepine 200mg tablets dispensed in Tripoli pharmacies, The physicochemical equivalence of five different Carbamazepine 200mg tablets was investigated through the evaluation of the uniformity of weight, thickness, diameter, friability, hardness, disintegration time, drug content as well as dissolution rate. The results of all the five brands of Carbamazepine 200mg tablets passed the official tests as prescribed by the pharmacopoeia standards including uniformity of weight, thickness, hardness, friability, disintegration time, drug content as well as dissolution rate. Acceptable external features as well as uniformity in diameter and thickness revealed for all the tablets. The entire brands complied with the official specifications for uniformity of weight where no tablet showed a deviation more than ±5%. Brand B had the highest crushing strength while brand D had the highest disintegration time compared to the other brands. All the brands had values within the range specified for friability and assay in the USP. The dissolution profiles showed that none of the brands had dissolution less than 75% within 60 minutes. The entire brands evaluated in this study could be considered bioequivalence, therefore it can be interchanged in clinical practice, and the patient can be safety switch from one brand to another. This sort of study is good indicator for the evaluation of the idealness of commercial products.
tamader youssef salem elghnimi(1-2022)
Publisher's website

Multilple myeloma: therapeutic delivery of antibodies and aptamers

Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation.
Manal M. Alsaadi(9-2021)
Publisher's website

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