The most common preparation of tocotrienols is the tocotrienol-rich fraction (TRF). This study aimed to investigate whether TRF induced liver Nrf2 nuclear translocation and influenced the expression of Nrf2-regulated genes. Methods: In the Nrf2 induction study, mice were divided into control, 2000 mg/kg TRF and diethyl maleate treated groups. After acute treatment, mice were sacrificed at specific time points. Liver nuclear extracts were prepared and Nrf2 nuclear translocation was detected through Western blotting. To determine the effect of increasing doses of TRF on the extent of liver nuclear Nrf2 translocation and its implication on the expression levels of several Nrf2-regulated genes, mice were divided into 5 groups (control, 200, 500 and 1000 mg/kg TRF, and butylated hydroxyanisole-treated groups). After 14 days, mice were sacrificed and liver RNA extracted for qPCR assay. Results: 2000 mg/kg TRF administration initiated Nrf2 nuclear translocation within 30 min, reached maximum level around 1 h and dropped to half-maximal levels by 24 h. Incremental doses of TRF resulted in dose-dependent increases in liver Nrf2 nuclear levels, along with concomitant dose-dependent increases in the expressions of Nrf2-regulated genes. Conclusion: TRF activated the liver Nrf2 pathway resulting in increased expression of Nrf2-regulated cytoprotective genes.
Ahmed Elbadri M Atia(9-2020)

Abstract Introduction: Provisional restoration is an important part of fixed prosthodontics. It must provide pulp protection, positional stability, occlusion maintenance , and space preservation. There are two methods for provisional restoration fabrication; direct and indirect techniques. Aim: the study aims to identify the most preferred technique of fabricating provisional fixed restorations according to different parameters and situations and to highlight the advantages and disadvantages of each technique, by specialist dentists practicing in different dental clinics in Tripoli. Methodology: In this study, 120 closed ended questionnaires were distributed to specialist dentists in dental fixed restoration among different private dental clinics in Tripoli/Libya to find out which technique they prefer to apply in their clinics. Results: This study has revealed that dentists prefer the direct technique for the anterior area and single unit and up to 3-4 units fixed partial denture. While indirect technique was more commonly used by dentists in cases of multi-units and posterior teeth. In addition, it has a higher success rate and does not cause pulpal and gingival irritation.
NARJES ELGHEZAWI HANAN IRHOMA , ABDUSSALAM ELJABALI (7-2021)

طالما أن الفرد والمجتمع متلازمان ولا ينفصلان، فإنه يجب تنظيم العلاقة بين سلطة الدولة وحريات الأفراد وبما أن ،في المجتمع الدستور يمثل وسيلة الحكم الديمقراطي في المجتمعات المتقدمة، فعليه تقع مهمة تنظيم هذه العلاقة تحيل كونه يس تصور مجتمع بشري بدون تشريع، فالرابطة الاجتماعية هي رابطة قانونية قبل كل شيء وحيث يكون المجتمع يكون القانون. وفي الواقع، لا تكون حماية ممارسة الحريات العامة دائما وفي كل مكان بنفس الطريقة، حتى داخل الدولة كما أن ال ،الواحدة حلول تختلف تبعا للحريات المعنية، أي تبعا للنشاط الإنساني المعني، وأنماط تنظيمها لا يقع دائما على ذات المستوى ، وإنما يتغير تبعا للحالات العادية التي يكون فيها المجتمع والظروف الاستثنائية التي تمر .بها البلاد لذلك فإن أساليب تنظيم الحرية ليست واحدة فقد تكون عن طريق الدستور أو القانون كما قد تكون عن طريق القرارات الإدارية التنظيمية .
حسام علي الحاج (6-2019)