كلية الصيدلة

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حول كلية الصيدلة

تأسست كلية الصيدلة سنة 1975م وتعتبر الكلية الأقدم في ليبيا للعلوم الصيدلانية، تهدف منذ بداية تأسيسها إلى المساهمة في الرفع من مستوى الخدمات الصحية للمواطن بليبيا والبدء جدياً في تطوير الخدمات الدوائية والدخول في هذا المجال على أسس علمية وبعد مُضي ما يزيد عن ثمانية وثلاثين عاماً على مولد هذه القلعة العلمية، لازالت هذه المؤسسة تزود المجتمع بشباب مؤهل ومؤمن بدوره في ليبيا الحرة ليقود مجالات الصناعة والرقابة الدوائية والتحاليل الطبية وترشيد استعمال الأدوية والاستفادة القصوى من الأعشاب والنباتات الطبية وبدأت الدراسة بالكلية مع بداية العام الدراسي 1976/1975م. واستمرت الدراسة بالمبنى القديم والذي تشغله الآن كلية الإعلام والفنون. وفي العام 1983م، تـــم إبـــرام عقد إنشاء مبنى جديد لكلية الصيدلة بجامعة طرابلس. وقد تم بناؤه على مساحــة تبلغ أربعـين آلف متر مربع “ 40.000 م2 “جنوب جامعة طرابلس. ويعتبر مبنى الكلية من أجمل مباني الجامعة حيث تم اختياره كأحد أجمل المباني التعليمية في العالم حسب تقرير أعدتـه المنظـــمة العــالمية للثقافــة والعلــــوم “اليونسكو“. يحد الكلية من ناحية الشرق كلية الطب البشرى لتشكل مع مركز طرابلس الطبي نموذجاً متميزاً للكليات الطبية التخصصية. هذه المؤسسة لا تزال ترعى منسبيها من الطلاب ليكونوا صيادلة المستقبل ولكي يشاركوا في بناء ليبيا.

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79

المنشورات العلمية

110

هيئة التدريس

1163

الطلبة

3188

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أ.د. مفتاح علي محمد الشوشني

د.مفتاح علي الشوشني هو احد اعضاء هيئة التدريس بقسم علم العقاقير بكلية الصيدلة. تحصل على الدكتوراة من دولة ألمانيا 2009.يعمل د.مفتاح الشوشني بجامعة طرابلس كـأستاذ وله العديد من المنشورات العلمية في مجال تخصصه

منشورات مختارة

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Physical Properties, Antibacterial and Antioxidant Properties of Raw South Africa Shea Butter against Samples from Libyan Market

Vigorous research has been conducted into the phenology of the shea tree, its usage and that of the shea butter extracted from the nuts of the shea fruit. Shea butter is the most valuable product in the Shea tree and its use as raw or in cosmetic and pharmaceutical products was expanded in the last years. The aim was to carry out comparative study between imported South African raw Shea Butter, one sample from Poland and samples from Libyan market on their physical properties (organoleptic), thin layer chromatography (TLC) chromatogram, phytochemical screening and diphenylpicrylhydrazil (DPPH) scavenging activity. As well as antimicrobial screening. Organoleptic test was carried out by comparing color and odor. TLC chromatogram was performed by spotting solution of samples in hexane on TLC plate and eluted twice in hexane: ethylacetate 8:2 to get good separation. Phytochemical screening was performed to determine the presence of carbohydrates (Fehling test), steroids, and triterpens (Salkwiski test). DPPH assay was carried out by spraying TLC sample spots by 0.2% DPPH methanolic solution. Antimicrobial test was conducted on Pseudomonas aeruginosa and Staphylococcus aureus. Mueller-Hinton agar was used with ciprofolxacin as +ve control and DMSO as–ve control. As a result, Shea Butter samples showed wide diversity in color and odor which considered normal except two white samples that might undergo refining process, while spreadability and TLC chromatograms were similar. Samples and control showed presence of carbohydrates, steroids and triterpens. Control and samples had DPPH scavenging activity. Shea Butter control and samples had no antimicrobial activities against P. aeruginosa and S. aureus. arabic 17 English 111
Sakina Salem Saadawi, Khairi Ali Alennabi, Hanin Nafed Mughrbi, Kholoud Lotfi, Nesrin Saleh Ali Abdulnabi(4-2020)
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Effect of Ion Channel Blockers on the Pharmacological Action of Paracetamol Using Albino Mice

Paracetamol is one of the most widely used drug as antipyretic and analgesic for mild to moderate pain. Currently, paracetamol is the first-line choice for pain management and antipyresis. Ion channels are pore-forming proteins that allow the flow of ions across membranes and involved in many cellular processes; drugs acting on ion channels have long been used for the treatment of many diseases. Objective: To estimate the effect of voltage gated ion channel blockers on analgesic activity of Paracetamol and explore the interaction between ion channel blockers and paracetamol on pain behaviour. Materials and Methods: Male albino mice were used. The central antinociceptive activity was determined by hot plate test and formalin test (Phase I; neuropathic pain). Antiinflammatory activity was determined by formalin test (Phase II). Intraperitoneal injection was adopted. Five groups of mice were used. Group 1; control group (1% T80), group 2; treated with (200mg/kg) paracetamol, group 3; treated with different drugs of ion channel blockers, group 4; received standard drugs, Aspirin (200mg/kg) for formalin test (phase II) or tramadol (5mg/kg) for hot plate test and formalin test (phase I), group 5; received combined treatment of ion channel blockers and paracetamol. Results: Pain produced by noxious stimuli (heat and formalin) was significantly reduced by acute administration of paracetamol. Inflammation pain produced by formalin injection was significantly decreased by acute administration of paracetamol. Acute administration of nifedipine showed significant decrease in nociception and inflammation pain. Combined treatment of nifedipine and paracetamol produced antinociceptive and anti-inflammatory activity but less than the additive effect. Verapamil has no analgesic effect in the two models, and did not change the affect of paracetamol analgesic activity when administered together. Phenytoin produces significant decrease in nociceptive pain using hot plate but not in formalin test (Phase I), and produce significant decrease in inflammatory pain (Phase II). The combined treatment of phenytoin and paracetamol showed analgesic activity less than the additive effect. 4-Aminopyridine produces significant antinociceptive and anti-inflammatory activity. The combined administration of 4-aminopyridine and paracetamol showed analgesic activity, which is less than the additive effect using formalin test, while paracetamol analgesic activity is potentiated by 4-aminopyridine using hot plate test. Conclusion: Paracetamol has antinociception and anti-inflammatory activity on pain model used (Hot plate test and Formalin test). Ion channel blockers produce antinociception and anti-inflammatory activity. Verapamil has no effect on nociception or inflammation pain and no effect on paracetamol analgesic activity. Nifedipine, phenytoin and 4-aminopyridine interact with paracetamol producing less additive analgesic effect, except 4-aminopyridine in thermal stimuli (Hot plate) is more sensitive compared to chemical stimuli (formalin test – phase I), where potentiates paracetamol action.
هناء مدحت الزقلعي (2014)
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Phytochemical, Antioxidant, Antibacterial and Nutritional value of Cucurbita maxima D (Cucurbitaceae) grown in Tripoli– Libya

ABSTRACT Pumpkin (Cucurbita maxima D.) is an angiosperm belonging to the Cucurbitaceae family generally characterized by climbing herbaceous vine with tendrils. The fruits vary in size, colour, shape and weight and have a moderately hard rind, with a thick edible flesh, and numerous seeds in the fruit which are either plump and tan or soft white.Preliminary phytochemical evaluation on different extracts of seed and fruit of C.maxima reveals the presence of proteins, carbohydrates, flavonoids, saponins, alkaloids, steroids, coumerins, phenolic compounds, terpenoids, and glycosides. A C.maximum contains antioxidants (such as: tocopherols, flavonoids, and phenolic acids, carotenoids or ascorbic acid) which are molecule that are capable of slowing or preventing the oxidation of other molecules. They may protect cells from damage caused by unstable molecules known as free radicals. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions by being oxidized themselves.Free radical scavenging or antioxidant activity of the extract was determined on the basis of their scavenging activity of the stable 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical. Antibacterial activity of the crude extract was determined by Cup-cut agar diffusion method.The pulp and seed extracts showed significant antioxidant activity in a dose-dependent manner with good IC50 values. For the pulp IC50(s) were 4.25 ± 0.05, 3.84 ± 1.18 and 4.12 ± 0.32 for petroleum ether, chloroform and Methanol extracts, respectively. In addition the the seed IC50(s) were 9.22 ± 0.20, 14.5 ± 0.14 and 5.97 ± 1.70 for petroleum ether, chloroform and Methanol extracts, respectively. C.maxima extracts contains antioxidants that prevent the oxidative damage to DNA in presence of DNA damaging agent (Sybr Gold) at a high concentration. The percentage of hydroxyl radical scavenging activity of C. maxima determines the ability of antioxidant to scavenge the hydroxyl radicals. The antioxidant activity of C. maxima extracts has high scavenging activity (thermodynamic property) and relatively high reaction rate (kinetic property); therefore, the second order rate constant (ks) of the H-atom transfer from antioxidant to the hydroxyl radical was seen. The seed extract showed antibacterial properties on both Gram- positive and Gram-negative bacteria used in this study. This means that C. maxima are useful as potential antibacterial agents. It was also observed from this study, the variations in the antibacterial activities of the C. maxima may be due to the differences in their bioactive compositions or concentrations. In conclusion, the physicochemical and preliminary phytochemical evaluation of fruit and seeds of C.maxima provide valuable information regarding their identification, authentication and chemical constituents which may be useful for the standardization and preparation of medicinal plants. The constituents of fruit and seeds of C. maxima may have several medicinal properties and can be utilized for the treatment of various diseases. Further research on this species in Libya may help in the isolation of therapeutically potent compounds which can be finally be subjected to pharmacological activities, thus leading to opening up new avenues in the use of natural products for therapeutic purpose.
إيناس عبدالله السعداوي (2016)
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